Dr Mirko Spiroski is a graduate of the Faculty of Medicine at the Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia (1972), where he later obtained his MSc (1978), and PhD (1989) degrees. He is the founder and Director of the Institute of Immunobiology and Human Genetics at the Faculty of Medicine in Skopje, Republic of Macedonia.

He introduced several subjects in the curricula at the Faculties of Medicine (Immunology and Human genetics), Natural Sciences (Immunochemistry with basic immunology, Biochemistry-3, Immunogenetics), Physical Education (Genetics in sport), and in the Master of Sciences postgraduate program in Public Health (Public health genetics). He introduced the subject Basics of Scientific Methodology in the curriculum of the School of Doctoral Studies at the Ss Cyril and Methodius University of Skopje, Republic of Macedonia.

His research interest is immunology, but he has also published in the fields of molecular anthropology and human genetics.

He was Secretary general and Deputy Editor-in-Chief of the journal Godishen zbornik na Medicinski Fakultet Skopje, and Editor-in-Chief of the Macedonian Journal of Medicine. Dr Mirko Spiroski is the founder and Editor-in-Chief of the Open Access Macedonian Journal of Medical Sciences, previously known as Macedonian Journal of Medical Sciences. He serve as Associate Editor of the journal Gene, as well as Consulting editor and expert at the Anthropological Researches and Studies.

From February 1, 2017, until December 31, 2017, he was employed at Zan Mitrev Clinic, Skopje, Republic of Macedonia. Starting of January 1, 2018, he was employed as Director in Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia.