Two new journals hope to harness the evidence in medical case reports. Cases Journal (www.casesjournal.com), launched by BioMed Central in May, is open access and peer reviewed and authors must pay £99 per report. BMJ Case Reports (http://casereports.bmj.com) is a free online journal launched in June. It charges authors an annual fee of £95, and they can submit as many reports as they like. Case reports are weak evidence but are a starting point for further research, the editors say. And together they might provide evidence for people with comorbities, who are often excluded from randomised trials. See www.guardian.co.uk/commentisfree/2008/may/14/medicine20.