B – Antidepressants. An untold story?

Lenzer J, Brownlee S. Antidepressants. An untold story? BMJ 2008;336:532-534


This story about antidepressants highlights the ongoing problem of how study results are often distorted by a failure to access full datasets. In fact, the analysis of published and unpublished data from studies of antidepressants in adults shows that only a very small subset of patients seemed to benefit. The problem of publication bias is pointed out through the tendency tp publish only positive studies and file away negative studies. On the contrary, all data should be made available to guarantee both patients and researchers.