B – High-information studies: highlighting the hypotheses

Editorial. Conclusion by exclusion. Nat Genet 2010;42:95.

Studies of systems models and biomarkers both present large amounts of information to publishers and readers. To aid review and readability, such studies should propose explicit hypotheses and demonstrate exclusion of competing explanations. To distinguish the direct influence of the research independently of the publications that describe it, hypotheses and experiments would be coded and separately cited. A study providing strong inferences will be both well used and highly cited.