B – Integrity of clinical trial evidence

Loder E, Godlee F, Barbour V, et al. Restoring the integrity of the clinical trial evidence base. BMJ 2013;346:f3601
(doi: 10.1136/bmj.f3601)

The authors stated that many completed trials have never been published, and many published results are incomplete or misleading. Hidden or misreported information from clinical trials is one of the leading scientific problems of our time. Peter Doshi and colleagues call on institutions that funded and investigators who conducted abandoned trials to publish (in the case of unpublished trials) or formally correct or republish (in the case of misreported trials) their studies. Their RIAT (restoring invisible and abandoned trials) proposal is here described. It provides a minimum set of criteria for the proper and responsible publication and republication of abandoned studies.