11 March 2015
The authors discuss the significant initiatives that the US National Institutes of Health is exploring to restore the self-correcting nature of preclinical research. They share the concern that the complex system for ensuring the reproducibility of biomedical research is failing. This has compromised the ability of today’s researchers to reproduce others’ findings demanding immediate and substantive action. The NIH is firmly committed to making systematic changes that should reduce the frequency and severity of this problem.