B – The erosion of research integrity

Ellis LM. The erosion of research integrity: the need for cultural change. The Lancet Oncology July 2015;16:752-754
(doi: 10.1016/S1470-2045(15)00085-6)

The success of drug development depends on robust and reproducible preclinical studies. Reports suggest that a high percentage of preclinical studies cannot be reliably reproduced. Causes could be sloppy research and data falsification or even fabrication. The author suggests approaches to improve data reproducibility, and fosters a complete cultural change.